Scientists Use AI to Boost Precision of Gene Editing

Scientists from the University of Zurich (UZH), Ghent University in Belgium, and the ETH Zurich have developed a new gene editing method that combines artificial intelligence (AI) with gene editing technologies to precisely edit DNA. The tool, called Pythia, could accelerate the development of safer gene therapies and improve disease modeling.

Phytia uses AI to predict how cells repair their DNA after it is cut by gene editing tools like CRISPR-Cas9. “Our team developed tiny DNA repair templates, which act like molecular glue and guide the cell to make precise genetic changes,” explained lead author Thomas Naert, a postdoctoral researcher at Ghent University. Tested first in human cell cultures, the method was later validated in animal models such as frogs and mice, where the team successfully edited DNA in brain cells.

The study found that DNA repair follows predictable patterns that AI can model and anticipate. This method could reduce unwanted mutations and increase control over edits. “Just as meteorologists use AI to predict the weather, we are using it to forecast how cells will respond to genetic interventions,” said Soeren Lienkamp, senior author and professor at UZH and ETH Zurich. The researchers said that the approach provides a strong foundation for safer, more effective gene therapies in the future.

For more information, read the article from the University of Zurich.