Biotech Updates

UC Davis Develops New Genetic Tool for Shorter Wheat

March 26, 2025

Scientist Juan Debernardi gives a thumbs-up to the short but upright grain on the left, which is dwarf triticale developed with a new genetic tool using micro-RNA. Thumbs-down is for the plot on the right, which is the original, tall triticale line. Debernardi is the manager of the Parsons Foundation Plant Transformation Facility at UC Davis. (Joshua Hegarty/UC Davis)

Scientists at the Department of Plant Sciences at the University of California Davis have developed a new genetic tool to easily breed wheat and triticale to grow more efficiently and to be better adapted to different environments. The new method recognizes that, in grasses such as wheat, small and short are different.

The method allows breeders to tease apart the genes that control plant height from genes that control the other aspects of a plant's growth and other qualities. With this method, breeders can now develop varieties of grain with a range of plant heights, so farmers can get seed better suited to the conditions of individual fields.

The team focused on the genes AP2L-B2 and AP2L-R2 which, when activated, make plants grow shorter. They used a revolutionary new discovery: micro-RNA. These tiny molecules regulate gene expression in plants and animals. In 2024, their discoverers won a Nobel Prize in Physiology or Medicine. Micro-RNAs do many different jobs. Some kinds are like tiny scissors, cutting out bits of genes and reducing those genes' impact. Using CRISPR-Cas9, the team introduced mutations that block the ability of a particular micro-RNA whose job is to snip the AP2L2 genes. That means the levels of the AP2L2 genes in the new plants were higher, and those plants grew shorter above ground. Snipping for different levels of AP2L2, the team could develop plants that grow at different heights.

The team reported that the method has produced superior results outside the lab. In field tests over two years, gene-edited plants were 5 to 7 inches (12 to 18 cm) shorter and better resisted falling over during storms, leading to a significant reduction in lodging and a 9 percent total increase in grain yield.

For more details, read the news release in the UC Davis College of Agricultural and Environmental Sciences.


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