Species: Cattle (Bos taurus)
Country of 1st Author: United States
Year:
2021
| Breed Strain | |
| Institute | |
| Editing Method | |
| SDN Type | |
| Delivery | |
| Foreign DNA | |
| Undergone Regulatory Process | No |
Target Gene(s)
| Gene Name | Gene Trait | Trait Category | NGT | Methods/Remarks |
| PRLR Prolactin Receptor |
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. | Abiotic Stress | CRISPR Cas9 (spCas9) | targeted editing was done on a single cell in the zygotes 12h after fertilization by introduction of guide (g)RNA/Cas9 (250 ng µL-1 of each) through intracytoplasmic microinjection. |
References, Documents, and Links