Species: Pig (Sus scrofa domesticus)

Country of 1st Author: China
Year: 2017

Breed Strain	Bama pigs
Institute	State Key Laboratory of Stem Cell and Reproductive Biology, Chinese Academy of Sciences Chaoyang District, Beijing CN
Editing Method	Cloned cell line
SDN Type	SDN-3
Delivery	Mouse adiponectin-UCP1 knocked into the porcine endogenous UCP1 locus.
Foreign DNA	Yes
Undergone Regulatory Process	No

Target Gene(s)

Gene Name	Gene Trait	Trait Category	NGT	Methods/Remarks
UCP1 Uncoupling protein 1	Improved ability to maintain body temperature during acute cold exposure	Abiotic Stress	CRISPR Cas9 (spCas9)	HDR-knockin

References, Documents, and Links

• Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity