Rabies Vaccine from GM Carrots
June 5, 2009| |
Researchers at the National Autonomous University of Mexico have developed transgenic carrot plants accumulating significant levels of the rabies virus glycoprotein. Rabies continues to be a major health problem worldwide, especially in developing countries, in spite of the availability of vaccines. The researchers believe that a vaccine expressed in an edible plant could provide a less expensive alternative.
The rabies glycoprotein gene was introduced to carrot embryogenic cells by particle bombardment. The scientists observed that all transformed plants presented a normal phenotype when compared to non-transformed plants. Mice immunized with the antigen were found to produce rabies antibodies and resist challenge.
The paper published by Transgenic Research is available at http://dx.doi.org/10.1007/s11248-009-9278-8
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