Expression of β-glucosidase Increases Trichome Density and Artemisinin Content in Sweet WormwoodSeptember 16, 2015
Artemisinin is effective against strains of Plasmodium falciparum, the causal agent of the most severe form of malaria. However, low accumulation of artemisinin in sweet wormwood (Artemisia annua) is a major limitation for production and delivery to malaria plague areas of the world. Several strategies to enhance artemisinin have been explored, however, enhancing storage capacity in trichomes has not yet been considered.
Nameirakpam Dolendro Singh of the CIBUS LLC US, together with other researchers, increased the trichome density through the expression of β-glucosidase (bgl1) gene in sweet wormwood. Trichome density increased up to 20% in leaves and 66% in flowers of transgenic plants compared to control plants. Further analysis data showed that artemisinin content increased up to 1.4% in leaves and 2.56% in flowers.
The study shows the possibility of increasing artemisinin content by manipulating trichomes' density. Combining genetic engineering with enhancing trichome density may further increase artemisinin yield in sweet wormwood.
For more information, read the full article in Plant Biotechnology Journal.
See more articles:
News from Around the World
- Farmers in Kenya Support Government Plan to Lift Ban on Biotech Crops
- Research Shows Caterpillars Trick Corn Plants to Lower their Defenses
- Genetic Engineering Transforms Common Plant to Produce Cancer Drug
- Scientists Asks for Deregulation of Bt eggplant to Unchoke Regulatory Pipeline in India
- U.S.-Pakistan Wheat Breeders' Cooperation Develops Unique Pool of Wheat Genetics to Fight Wheat Diseases
- Chinese Scientists Complete Genome Sequence of Bacillus thuringiensis Strain HD521
- New Method to Predict Plant Size at Maturity Based on Genetic Markers
- EU Regulators and Food Suppliers Can Now Access Online GM Crop Database
- GM Plants Could Help Eliminate Food Poisoning
- Expression of β-glucosidase Increases Trichome Density and Artemisinin Content in Sweet Wormwood
Beyond Crop Biotech
- Scientists Reveal Novel Genes Affecting Sex Determination in Yellow Catfish
From the BICs
- Ugandan Scientists and Journalists Strive to Find a Middle Ground
- Filipino Experts and Agri Stakeholders Discuss Gender and GM Crops
- Biotech Crop Annual Updates
- New Infographic Shows Process of Getting GM Crops to Market
Subscribe to CBU: