Making Bacteria a Disease Diagnostic Tool
June 10, 2015| |
A group of researchers from Institut National de la Santé et de la Recherche Médicale (INSERM), French National Centre for Scientific Research (CNRS), Montpellier Regional University Hospital and Stanford University designed a bacteria to function as a disease diagnostic tool in assessing urine and blood samples.
This was done by modifying the bacteria through the insertion of a genetic transistor, the transciptor. The transciptor functions as a switch and signal amplifier, making it possible to implant simple genetic programmes into living cells in response to different combination of molecules. Its insertion has given the ability for bacteria to detect disease markers even at small amounts and the ability to store the results of the tests in several months.
Its efficiency was proven when the modified bacteria were able to detect the abnormal presence of glucose in urine samples obtained from diabetic patients.
Read full details of their study at INSERM's website.
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