Recombinant Viral Vector Expressing hBD4 Inhibits Bacterial Infection in Burn Wounds
October 8, 2014| |
Burn patients can be affected by infection, hypovolemic shock, hypothermia, and respiratory failure. First aid is critical for the prevention of these severe complications. However, secondary bacterial infection is hard to control in burn patients, and Pseudomonas aeruginosa is one of the top pathogens tormenting burn wounds.
To prevent complications in burn patients, researchers led by Man-Seong Park from Korea University, assessed the in vitro and in vivo inhibitory values of human β-defensin 4 (hBD4), a known member of antimicrobial peptides found in human cells. The recombinant Newcastle disease virus (rNDV-hBD4) was used as the vector for hBD4 in burn wounds. HBD4 effectively inhibited growth of Pseudomonas in culture media and healed severely burned skin in mice with burn wounds. Results suggest that application of hBD4 may protect burn patients from secondary Pseudomonal infection and provide a therapeutic burn wound treatment.
Learn more about the study here: http://www.biomedcentral.com/1471-2229/14/260.
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