Shrimps Now Take Oral Medicine for Yellow-Head Virus
April 23, 2014| |
Yellowhead virus (YHV) is a major pathogen of penaeid shrimp species. YHV outbreaks cause economic loss of millions of US dollars in Thailand. Therefore, a potent and practical treatment of this disease is needed. Previous studies have demonstrated that YHV replication is strongly inhibited by injection of dsRNA corresponding to either viral protease gene (dsYHV) or shrimp Rab7 gene (dsRab7) and that shrimp mortality was suppressed. Although this approach against YHV via dsRNA injection has been well demonstrated for years, it is not adopted in a farm culture due to its impracticality.
Oral administration of dsRNA is the next alternative approach. Hence, oral feeding of Escherichia coli expressing shrimp Rab7 gene(dsRab7) or YHV protease gene (dsYHV) was tested if it could inhibit YHV replication and lower shrimp mortality. E. coli HT115 expressing dsRab7 or dsYHVor a combination of these dsRNAs were embedded in agar and were fed to shrimp at early juvenile stage before YHV. After 4 days of continuous feeding, strong inhibitory effect on shrimp mortality was observed in which dsRab7 gave the highest effect, peaking at 70% reduction from the control while dsYHV showed a 40 percent reduction. This suggests a significant silencing of shrimp Rab7 mRNA expression achieved by orally-delivered dsRab7.
These results reveal the great potential anti-YHV strategy via orally delivered dsRNA for application in the shrimp farm industry.
Read more here: http://www.sciencedirect.com/science/article/pii/S0168165614001199.
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