Novel Approach Shows Biomarkers for Development and Disease
January 31, 2024| |
Scientists from Singapore developed a novel approach to sequence single-cell RNA. This method will help examine the roles of RNA structure in single cells.
RNA structure is essential for several stages of gene regulation. However, how transcript structures differ within and between different cells is unknown.
That's why researchers from A*STAR's Genome Institute of Singapore produced Single Cell Structure Probing Of RNA Transcripts (Sc-SPORT) that simultaneously analyzes secondary structure and abundance at a single cell level. The technique can acquire information from RNA structure to determine cell types in diseases and development. The RNA structure could also be used as a potential biomarker or drug target for disorders with stable RNA levels.
Read the journal article on Nature Methods for more information.
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