Developer:
Monsanto Company (including fully and partly owned companies)

Method of Trait Introduction:
Conventional breeding - cross hybridization and selection involving transgenic donor(s)

GM Trait s :
Lepidopteran insect resistance , Antibiotic resistance , Visual marker

Commercial Trait:
(Stacked)  Insect Resistance

Summary of Basic Genetic Modification

Gene Introduced	Gene Source	Product	Function
vip3A(a)	Bacillus thuringiensis strain AB88	VIP3A vegetative insecticidal protein	confers resistance to feeding damage caused by lepidopteran insects by selectively damaging their midgut lining
aph4 (hpt)  *	Escherichia coli	hygromycin-B phosphotransferase (hph) enzyme	allows selection for resistance to the antibiotic hygromycin B
cry1Ac	Bacillus thuringiensis subsp. Kurstaki strain HD73	Cry1Ac delta-endotoxin	confers resistance to lepidopteran insects by selectively damaging their midgut lining
cry2Ab2	Bacillus thuringiensis subsp. kumamotoensis	Cry2Ab delta-endotoxin	confers resistance to lepidopteran insects by selectively damaging their midgut lining
nptII  *	Escherichia coli Tn5 transposon	neomycin phosphotransferase II enzyme	allows transformed plants to metabolize neomycin and kanamycin antibiotics during selection
aad  *	Escherichia coli	3''(9)-O-aminoglycoside adenylyltransferase enzyme	allows selection for resistance to aminoglycoside antibiotics such as spectinomycin and streptomycin
uidA  *	Escherichia coli	beta-D-glucuronidase (GUS) enzyme	produces blue stain on treated transformed tissue, which allows visual selection

 * : Selection Marker/Reporter  

Summary of Regulatory Approvals: Country, Year and Type of Approval

Country	Food direct use or processing	Feed direct use or processing	Cultivation domestic or non-domestic use
Australia
Japan
Mexico

 

Event Description

• Office of the Gene Technology Regulator - Australia

Regulatory and Biosafety Information

• CIBIOGEM - Mexico
• Japan Biosafety Clearing House
• Ministry of Health, Labor and Welfare - Japan
• Office of the Gene Technology Regulator - Australia
• Office of the Gene Technology Regulator - Australia