Species: Sheep (Ovis aries)

Country of 1st Author: China
Year: 2019

Institute	College of Animal Science and Technology, Northwest A&F University Yangling 712100 CN
Editing Method	Embryo edit
SDN Type	SDN-1
Delivery	co-injection of BE3 mRNA and a single guide RNA (sgRNA) into sheep zygotes.
Foreign DNA	No
Undergone Regulatory Process	No

Target Gene(s)

Gene Name	Gene Trait	Trait Category	NGT	Methods/Remarks
SOCS2 suppressor of cytokine signaling 2	High growth	Yield	DNA base editor	co-injection of BE3 mRNA and a single guide RNA (sgRNA) into sheep zygotes

References, Documents, and Links

• Programmable Base Editing of the Sheep Genome Revealed No Genome-Wide Off-Target Mutations