Scientists Find New Specific Insecticide Target Protein

Scientists from BASF and the University of Göttingen in Germany have found a new insecticide target protein. The discovery marks the first identification of vanilloid receptors, the TRPV ion channels, as insecticide targets. The scientists focused on the mode of action of the insecticides pymetrozine and pyrifluquinanzon and identified a novel TRPV ion channel complex as the target protein of the two chemicals. In insects, two TRPV channels exist, which occur together in certain stretch receptors that are present in joints, for example in the antennae and legs.

The two insecticides only act selectively on these stretch receptors because they activate an ion channel complex formed by the two TRPV channels. By activating this TRPV channel complex, the insecticides overstimulate the stretch receptors, disturbing insect locomotion and feeding. Substances with this mode of action are effective against many plant-sucking pests, particularly whiteflies and aphids.

Knowing the exact target of pymetrozine and pyrifluquinanzon will help the industry to provide better advice on spray programs to farmers. Dr. Vincent Salgado, a biologist at BASF Crop Protection said, "For instance, we would not want to treat fields with these two substances one after the other. The more you attack one particular site, the faster insects will become resistant. The findings help us to use insecticides more wisely and more sustainably."

For more details, read the news release at the University of Göttingen website.