BRAT1 Deficiency Leads to Mitochondrial Malfunction
July 30, 2014| |
BRAT1 (BRCA1-associated ATM activator 1) is involved with DNA damage responses in humans. However, based on previous studies, BRAT1 may also be involved in cell growth and apoptosis, implying its other functions. Toru Ouchi and Eui Young So from Roswell Park Cancer Institute in New York now search for unknown functions of BRAT1.
Different human cancer cells that do not express BRAT1 gene, or BRAT1 knockdown cells, were generated. These were then evaluated for cell growth properties and tumor growth potential compared to normal cancer cells. Loss of BRAT1 in the knockdown cells significantly decreased cell proliferation and tumor growth. It also induced mitochondrial malfunctions which led to growth retardation in BRAT1 knockdown cells. These results show the roles of BRAT1 in cell proliferation and mitochondrial functions of cancer cells and its importance in the search for cancer cure.
For more on the BRAT1 study, please visit: http://www.biomedcentral.com/1471-2407/14/548/abstract
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