Crop Biotech Update

Comparison of GM and Native Mustard's Allerginicity

October 17, 2012

Scientist Amita Misra from CSIR-Indian Institute of Toxicology Research and colleagues investigated the allergenic potential of genetically modified mustard (V4) with improved carotenoid content compared with native mustard.

They conducted simulated gastric fluid (SGF) digestibility of crude protein extract from GM mustard and from native mustard as well as IgE immunoblotting. They used BALB/c mice as a model for allergenicity studies. They monitored the total and specific IgE, specific IgG1, histamine level, histopathology, and systematic anaphylaxis score. Allergenicity of mustard was checked in humans through clinical history, skin test, and IgE levels.

Increase in total IgE, specific IgE, IgG1, histamine levels were observed in both GM and native mustard compared with the control. Anaphylactic symptoms and eruptive hispathological changes were caused by both GM and native mustard. Based on these findings, the GM and native mustard pose substantially equivalent allergic reactions to the models, which may imply that the GM mustard is as safe as the non-GM counterpart in terms of allergenicity.

Read the abstract at