Researchers Enhances Oil Production in Yeast Through CRISPR

At the University of California, researchers have adapted the CRISPR-Cas9 gene editing system for use in a yeast strain that can produces useful lipids and polymers. The development could lead to new precursors for biofuels, polymers, adhesives and fragrances.

CRISPR-Cas9 is a groundbreaking technique that enables scientists to make precise targeted changes in living cells. Unlike traditional gene-editing methods, it is cheap, easy to use and effective in almost any organism.

The research involves the oil-producing yeast Yarrowia lipolytica, known for converting sugars to lipids and hydrocarbons. The CRISPR-Cas9 allowed scientists to tap into the yeast's biomanufacturing potential. The team used CRISPR-Cas9 to knock genes out and introduce new genes, both useful tools in biomanufacturing.

The work was the first step in creating long chain hydrocarbons from yeast rather than synthetically. Other researchers may use the system to create precursors for biofuels, reducing the current reliance on edible plant oils.