Event Name: MON88913 x MON15985
Event Code : MON-88913-8 x MON-15985-7
Trade Name: Roundup Ready™ Flex™ Bollgard II™ Cotton
Crop: Gossypium hirsutum L. - Cotton
Developer: Monsanto Company (including fully and partly owned companies)
Method of Trait Introduction: Conventional breeding - cross hybridization and selection involving transgenic donor(s)
GM Traits: Glyphosate herbicide tolerance , Lepidopteran insect resistance , Antibiotic resistance , Visual marker
Commercial Trait: (Stacked) Herbicide Tolerance (HT) + Insect Resistance (IR)
Basic Genetic Modification
| Gene Introduced | Gene Source | Product | Function |
| cp4 epsps (aroA:CP4) | Agrobacterium tumefaciens strain CP4 | herbicide tolerant form of 5-enolpyruvulshikimate-3-phosphate synthase (EPSPS) enzyme | decreases binding affinity for glyphosate, thereby conferring increased tolerance to glyphosate herbicide |
| cry2Ab2 | Bacillus thuringiensis subsp. kumamotoensis | Cry2Ab delta-endotoxin | confers resistance to lepidopteran insects by selectively damaging their midgut lining |
| cry1Ac | Bacillus thuringiensis subsp. Kurstaki strain HD73 | Cry1Ac delta-endotoxin | confers resistance to lepidopteran insects by selectively damaging their midgut lining |
| uidA * | Escherichia coli | beta-D-glucuronidase (GUS) enzyme | produces blue stain on treated transformed tissue, which allows visual selection |
| nptII * | Escherichia coli Tn5 transposon | neomycin phosphotransferase II enzyme | allows transformed plants to metabolize neomycin and kanamycin antibiotics during selection |
| aad * | Escherichia coli | 3''(9)-O-aminoglycoside adenylyltransferase enzyme | allows selection for resistance to aminoglycoside antibiotics such as spectinomycin and streptomycin |
Regulatory Approvals: Country, Year and Type of Approval
| Country | Food direct use or processing |
Feed direct use or processing |
Cultivation domestic or non-domestic use |
| Argentina | |||
| Australia | |||
| Brazil | |||
| Colombia | |||
| Costa Rica | |||
| Japan | |||
| Mexico | |||
| New Zealand | |||
| Paraguay | |||
| Philippines | |||
| South Africa | |||
| South Korea | |||
| Taiwan |
* point mouse arrow over year for notes
Last updated: November 6, 2023
Documents and Links
Event Description
Regulatory and Biosafety Information
- AgroNews Paraguay
- CBD Biosafety Clearing House
- FAO GM Foods Platform
- Japan Biosafety Clearing House
- Office of the Gene Technology Regulator - Australia
- Taiwan Food and Drug Administration
Detection Methods
The GM Approval Database, or GMAD, is one of ISAAA’s unique features that compiles all the available information about biotech/GM crops that have been approved for planting and importation for food and feed, and commercialization. ISAAA sources out the information from publicly available decision documents per country, Biosafety Clearing Houses and peer-reviewed scholarly articles to maintain the credibility of the database. Your contribution can help expand and maintain the GMAD and make useful information more available to researchers, students, and the general public. You can help by donating as little as $10.