Event Name: GHB614 x T304-40 x GHB119 x COT102
Event Code : BCS-GHØØ2-5 x BCS-GHØØ4-7 x BCS-GHØØ5-8 x SYN-IR1Ø2-7
Trade Name: GlyTol LibertyLink TwinLink® Plus
Crop: Gossypium hirsutum L. - Cotton
Developer: Bayer CropScience (including fully and partly owned companies)
Method of Trait Introduction: Conventional breeding - cross hybridization and selection involving transgenic donor(s)
GM Traits: Glufosinate herbicide tolerance , Glyphosate herbicide tolerance , Lepidopteran insect resistance , Antibiotic resistance
Commercial Trait: (Stacked) Herbicide Tolerance (HT) + Insect Resistance (IR)
Basic Genetic Modification
| Gene Introduced | Gene Source | Product | Function |
| 2mepsps | Zea mays | 5-enolpyruvyl shikimate-3-phosphate synthase enzyme (double mutant version) | decreases binding affinity for glyphosate, thereby increasing tolerance to glyphosate herbicide |
| cry1Ab | Bacillus thuringiensis subsp. kurstaki | Cry1Ab delta-endotoxin | confers resistance to lepidopteran insects by selectively damaging their midgut lining |
| cry2Ae | Bacillus thuringiensis subsp Dakota | Cry2Ae delta-endotoxin | confers resistance to lepidopteran insects by selectively damaging their midgut lining |
| bar | Streptomyces hygroscopicus | phosphinothricin N-acetyltransferase (PAT) enzyme | eliminates herbicidal activity of glufosinate (phosphinothricin) herbicides by acetylation |
| vip3A(a) | Bacillus thuringiensis strain AB88 | VIP3A vegetative insecticidal protein | confers resistance to feeding damage caused by lepidopteran insects by selectively damaging their midgut lining |
| aph4 (hpt) * | Escherichia coli | hygromycin-B phosphotransferase (hph) enzyme | allows selection for resistance to the antibiotic hygromycin B |
Regulatory Approvals: Country, Year and Type of Approval
| Country | Food direct use or processing |
Feed direct use or processing |
Cultivation domestic or non-domestic use |
| Argentina | |||
| Australia | |||
| Brazil | |||
| Colombia | |||
| Japan | |||
| Mexico | |||
| Paraguay | |||
| Philippines | |||
| South Korea | |||
| Taiwan |
Last updated: July 15, 2024
Documents and Links
Event Description
Regulatory and Biosafety Information
The GM Approval Database, or GMAD, is one of ISAAA’s unique features that compiles all the available information about biotech/GM crops that have been approved for planting and importation for food and feed, and commercialization. ISAAA sources out the information from publicly available decision documents per country, Biosafety Clearing Houses and peer-reviewed scholarly articles to maintain the credibility of the database. Your contribution can help expand and maintain the GMAD and make useful information more available to researchers, students, and the general public. You can help by donating as little as $10.