Event Name: 4114 x MON87411 x DAS40278
Event Code : DP-ØØ4114-3 x MON-87411-9 x DAS-4Ø278-9
Trade Name: Enlist™
Crop: Zea mays L. - Maize, Corn
Developer: Dow AgroSciences LLC and DuPont (Pioneer Hi-Bred International Inc.)
Method of Trait Introduction: Conventional breeding - cross hybridization and selection involving transgenic donor(s)
GM Traits: Glufosinate herbicide tolerance , Glyphosate herbicide tolerance , Coleopteran insect resistance , Lepidopteran insect resistance , 2,4-D herbicide tolerance
Commercial Trait: (Stacked) Herbicide Tolerance (HT) + Insect Resistance (IR)
Basic Genetic Modification
| Gene Introduced | Gene Source | Product | Function |
| cry1F | Bacillus thuringiensis var. aizawai | Cry1F delta-endotoxin | confers resistance to lepidopteran insects by selectively damaging their midgut lining |
| cry34Ab1 | Bacillus thuringiensis strain PS149B1 | Cry34Ab1 delta-endotoxin | confers resistance to coleopteran insects particularly corn rootworm by selectively damaging their midgut lining |
| cry35Ab1 | Bacillus thuringiensis strain PS149B1 | Cry35Ab1 delta-endotoxin | confers resistance to coleopteran insects particularly corn rootworm by selectively damaging their midgut lining |
| pat | Streptomyces viridochromogenes | phosphinothricin N-acetyltransferase (PAT) enzyme | eliminates herbicidal activity of glufosinate (phosphinothricin) herbicides by acetylation |
| cry3Bb1 | Bacillus thuringiensis subsp. kumamotoensis | Cry3Bb1 delta endotoxin | confers resistance to coleopteran insects particularly corn rootworm by selectively damaging their midgut lining |
| cp4 epsps (aroA:CP4) | Agrobacterium tumefaciens strain CP4 | herbicide tolerant form of 5-enolpyruvulshikimate-3-phosphate synthase (EPSPS) enzyme | decreases binding affinity for glyphosate, thereby conferring increased tolerance to glyphosate herbicide |
| dvsnf7 | Western Corn Rootworm (Diabrotica virgifera virgifera) | double-stranded RNA transcript containing a 240 bp fragment of the WCR Snf7 gene | RNAi interference resulting to down-regulation of the function of the targeted Snf7 gene leading to Western Corn Rootworm mortality. |
| aad-1 | synthetic form of the aad-1 gene from Sphingobium herbicidovorans | aryloxyalkanoate dioxygenase 1 (AAD-1) protein | detoxifies 2,4-D herbicide by side-chain degradation and degrades the R-enantiomers of aryloxyphenoxypropionate herbicides |
Regulatory Approvals: Country, Year and Type of Approval
| Country | Food direct use or processing |
Feed direct use or processing |
Cultivation domestic or non-domestic use |
| European Union |
Last updated: October 12, 2023
Documents and Links
Event Description
The GM Approval Database, or GMAD, is one of ISAAA’s unique features that compiles all the available information about biotech/GM crops that have been approved for planting and importation for food and feed, and commercialization. ISAAA sources out the information from publicly available decision documents per country, Biosafety Clearing Houses and peer-reviewed scholarly articles to maintain the credibility of the database. Your contribution can help expand and maintain the GMAD and make useful information more available to researchers, students, and the general public. You can help by donating as little as $10.