Event Name: NK603 x MON810 x 4114 x MIR604
Event Code : MON-00603-6 x MON-00810-6 x DP004114-3 x SYN-IR604-4
Trade Name: Not available
Crop: Zea mays L. - Maize, Corn
Developer: Syngenta and Monsanto Company
Method of Trait Introduction: Conventional breeding - cross hybridization and selection involving transgenic donor(s)
GM Traits: Glufosinate herbicide tolerance , Glyphosate herbicide tolerance , Coleopteran insect resistance , Lepidopteran insect resistance , Antibiotic resistance , Mannose metabolism
Commercial Trait: (Stacked) Herbicide Tolerance (HT) + Insect Resistance (IR)
Basic Genetic Modification
| Gene Introduced | Gene Source | Product | Function |
| cp4 epsps (aroA:CP4) | Agrobacterium tumefaciens strain CP4 | herbicide tolerant form of 5-enolpyruvulshikimate-3-phosphate synthase (EPSPS) enzyme | decreases binding affinity for glyphosate, thereby conferring increased tolerance to glyphosate herbicide |
| cry1Ab | Bacillus thuringiensis subsp. kurstaki | Cry1Ab delta-endotoxin | confers resistance to lepidopteran insects by selectively damaging their midgut lining |
| cry1F | Bacillus thuringiensis var. aizawai | Cry1F delta-endotoxin | confers resistance to lepidopteran insects by selectively damaging their midgut lining |
| cry34Ab1 | Bacillus thuringiensis strain PS149B1 | Cry34Ab1 delta-endotoxin | confers resistance to coleopteran insects particularly corn rootworm by selectively damaging their midgut lining |
| cry35Ab1 | Bacillus thuringiensis strain PS149B1 | Cry35Ab1 delta-endotoxin | confers resistance to coleopteran insects particularly corn rootworm by selectively damaging their midgut lining |
| pat | Streptomyces viridochromogenes | phosphinothricin N-acetyltransferase (PAT) enzyme | eliminates herbicidal activity of glufosinate (phosphinothricin) herbicides by acetylation |
| goxv247 * | Ochrobactrum anthropi strain LBAA | glyphosate oxidase | confers tolerance to glyphosate herbicides by degrading glyphosate into aminomethylphosphonic acid (AMPA) and glyoxylate |
| nptII * | Escherichia coli Tn5 transposon | neomycin phosphotransferase II enzyme | allows transformed plants to metabolize neomycin and kanamycin antibiotics during selection |
| pmi * | Escherichia coli | Phosphomannose Isomerase (PMI) enzyme | metabolizes mannose and allows positive selection for recovery of transformed plants |
Regulatory Approvals: Country, Year and Type of Approval
| Country | Food direct use or processing |
Feed direct use or processing |
Cultivation domestic or non-domestic use |
| Canada | |||
| Colombia | |||
| Japan | |||
| Mexico | |||
| South Korea | |||
| Taiwan |
* point mouse arrow over year for notes
Last updated: August 19, 2018
Documents and Links
Regulatory and Biosafety Information
The GM Approval Database, or GMAD, is one of ISAAA’s unique features that compiles all the available information about biotech/GM crops that have been approved for planting and importation for food and feed, and commercialization. ISAAA sources out the information from publicly available decision documents per country, Biosafety Clearing Houses and peer-reviewed scholarly articles to maintain the credibility of the database. Your contribution can help expand and maintain the GMAD and make useful information more available to researchers, students, and the general public. You can help by donating as little as $10.