CorA Affects Virulence and Enzyme Production in the Soft Rot Pathogen
December 9, 2011| |
Pectobacterium carotovorum is a bacterium that causes soft rot disease in a wide variety of plants including carrots and potato. Virulence in soft rot bacteria is driven by environmental factors, host and bacterial chemical signals, and a number of gene-specific bacterial regulators. A team of researchers led by Caleb Kersey of the Tennessee State University isolated a mutant of P. carotovorum that have reduced production of pectate lyase, protease, polygalacturonase, and cellulose. The researchers observed decreased virulence as it macerates less host tissues than its parent and is severely impaired in multiplication. The gene responsible for this reduction in virulence was found to be corA, which codes for a magnesium/nickel/cobalt membrane transporter. When compared with its parent, the mutant was found to be cobalt resistant. These results indicate that CorA is important for exoenzyme production and virulence in P. carotovorum.
Read the abstract at http://onlinelibrary.wiley.com/doi/10.1111/j.1364-3703.2011.00726.x/abstract.
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