Scientists Sequence Human Liver Fluke Genome
October 28, 2011| |
A team of scientists led by Xiaoyun Wang from Sun Yat-sen University has sequenced the genome of the carcinogenic human live fluke (Clonorchis sinensis). Previous studies have shown that the infection rate of this parasite is significantly linked to the incidence of cholangiocarcinoma, the formation of cancerous tumors in the bile ducts. To unfold the mystery behind this relationship and find treatment, the genome of C. sinensis was sequenced.
The genome revealed that there are missing genes involved in the production of fatty acids, which indicates the parasitic lifestyle of a liver fluke that receives lipids from the bile of its host. The researchers also identified pathogenic molecules that may contribute to live fluke-induced disease in the liver, gall bladder, and bile ducts. Large proteins were found to be potential targets for development of drugs and diseases.
Read the report at http://genomebiology.com/2011/12/10/R107/abstract.
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