CYP1B1 Promotes Proliferation of Renal Cell Carcinoma via Expression of Cell Division Regulator
December 2, 2015| |
Cytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer, including renal cell carcinoma (RCC). Reports have shown that CYP1B1 can influence the regulation of tumor development, however, its role in RCC has not been well studied.
Researchers first confirmed that CYP1B1 protein expression was significantly higher in RCC cell lines compared to normal kidney tissue. CYP1B1 expression was also found to be associated with tumor grade and stage.
To determine the biological significance of CYP1B1 in RCC progression, the gene was silenced through RNA interference and were subjected to various analyses. Silencing the CYP1B1 resulted in decreased cell proliferation, migration and invasion of RCC cells.
CYP1B1 may promote RCC development by inducing expression of CDC20, a regulator of cell division. The results demonstrate that CYP1B1 can be a potential target for anticancer therapy in RCC.
For more information, read the full article in BMC Cancer.
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