Overexpressed YML131W Gene Gives Saccharomyces cerevisiae Furfural Tolerance During Plant Biomass Conversion
August 20, 2014http://link.springer.com/article/10.1007/s12155-014-9506-9/fulltext.html
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Furfural is one of the main aldehyde inhibitors generated in the pretreatment of plant biomass. The study, conducted by researchers from the Sichuan Agricultural University in China, reports of an uncharacterized gene, YML131W, highly induced by furfural stress conditions.
YML131W was found to code for an aldehyde reductase, which is involved in detoxifying toxic aldehydes, including furfural. This role would help to maintain cell viability under furfural stress conditions. A Saccharomyces cerevisiae strain overexpressing YML131W showed increased tolerance to furfural and was able to catalyze the conversion of aldehydes to alcohols, indicating its potential in producing fuels.
The team identified 15 proteins from 14 yeast species with similarities to YML131W. These other proteins likely have similar functions as YML131W and may have potential to confer tolerance to aldehyde inhibitors.
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