LSTM Researchers Explain Multiple Insecticide Resistance in Mosquitoes

Scientists at Liverpool School of Tropical Medicine in the UK revealed the reason behind the multiple and extreme-level resistance in mosquitoes found in the rice fields of Tiassalé in southern Côte d'Ivoire discovered in 2011. The results of their investigation are published in PLoS Genetics.

The researchers combined stringently-replicated whole genome transcription profiling, in vivo transgenic gene expression, and in vitro metabolism assays to search for genes P450 detoxification enzyme superfamily which are highly expressed in the adult females from the area. The study reveals that two members of the P450 gene superfamily (CYP6M2 and CYP6P3) in particular are highly expressed in resistant mosquitoes. When the genes were transferred into Drosophila, resistance to pyrethroids and carbamates was generated in supposed to be susceptible fly strains. These genes are familiar candidates to LSTM researchers who have previously documented their links with pyrethroid and DDT resistance. This results show how specific P450 genes can engender resistance across insecticides with entirely different modes of action.

For more details, visit http://www.lstmliverpool.ac.uk/about-lstm/news-and-media/press-releases/researchers-at-lstm-unlock-the-secret-of-multiple-insecticide-resistance-in-mosquitoes.